| Autor: |
F.D. Dapper, H.D. Boettcher, H. von Lieven, B. Rosskopf, I.A. Adamietz |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
European Journal of Cancer. 31:S51 |
| ISSN: |
0959-8049 |
| DOI: |
10.1016/0959-8049(95)95493-p |
| Popis: |
Background Iatrogenic leukopenia can cause radiotherapy to be delayed or discontinued. This complication can be overcome with the use of granulocyte colony-stimulating factor (G-CSF). However, great uncertainty exists regarding the mode of application of G-CSF in patients treated with radiotherapy. For this reason, the efficacy of two strategies for the administration of G-CSF in irradiated patients was compared in a prospective randomized clinical study. Material and Methods Fortyone patients who developed leukopenia whilst undergoing radiotherapy were treated with G-CSF at a daily dose of 5 μg per kg. The first group received single injections of G-CSF as and when required (n = 21). The second group received G-CSF on at least 3 consecutive days (n = 20). Results An increase in leucocyte values in the peripheral blood was observed in all patients treated with G-CSF. In the group which received G-CSF when required, two injections (range: 1–8) were administered in most cases. In the second group, most of the patients received 3 injections (range: 3–9). The average duration of therapy interruptions was 4.8 days (0–28) in the first therapy arm and 2.5 (0–20) in the second arm. The variance in the duration of therapy interruptions between the 2 groups was not significant ( P = 0.2). Radiotherapy had to be terminated in 2 patients due to thrombocytopenia. Conclusion Our results reveal that G-CSF is effective in the treatment of radiogenic leukopenia regardless of the mode of application. The administration of G-CSF on several consecutive days tends to reduce the number of therapy interruptions more effectively than single injections given when required. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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