Taurine Inhibits TRPV-Dependent Activity to Overcome Oxidative Stress in Caenorhabditis elegans
| Autor: | Mariam Piruzyan, Mary Ann Suico, Shingo Matsuyama, Yoshio Nakano, Yu Tsurekawa, Tsuyoshi Shuto, Masataka Moriuchi, Hirofumi Kai, Hirofumi Nohara |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Agonist Taurine biology medicine.drug_class TRPV1 Pharmaceutical Science General Medicine biology.organism_classification medicine.disease_cause TRPV Cell biology 03 medical and health sciences Transient receptor potential channel chemistry.chemical_compound HaCaT 030104 developmental biology 0302 clinical medicine chemistry 030220 oncology & carcinogenesis medicine lipids (amino acids peptides and proteins) Caenorhabditis elegans Oxidative stress |
| Zdroj: | Biological and Pharmaceutical Bulletin. 41:1672-1677 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b18-00370 |
| Popis: | Taurine has important physiological roles as well as a wide range of pharmacological effects. Studies have suggested that taurine ameliorates diabetes, hypertension, oxidative stress, and inflammatory diseases. However, its mechanisms of action are still unclear. It has been reported that N-acyl taurine activates transient receptor potential vanilloid-1 (TRPV1), which is related to the pathogenesis of many inflammatory diseases. In this study, we hypothesized that taurine has a regulatory effect on TRPV1 activation via N-acyl taurine. To evaluate this hypothesis, we assessed the calcium influx activated by a TRPV1 agonist in human keratinocyte (HaCaT) cells and paraquat-induced oxidative stress in Caenorhabditis elegans. Our results indicate that taurine inhibits TRPV-dependent activity to overcome oxidative stress in cultured cell lines and in C. elegans. |
| Databáze: | OpenAIRE |
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