Ratchet patterns sort molecular shuttles

Autor:	George D. Bachand, Carolyn M. Matzke, John Clemmens, Henry Hess, Viola Vogel, Bruce C. Bunker
Rok vydání:	2002
Předmět:	Persistence length Quantitative Biology::Biomolecules Physics::Biological Physics Chemistry Brownian ratchet Ratchet General Chemistry Curvature Quantitative Biology::Subcellular Processes Motor protein Classical mechanics Rigidity (electromagnetism) Microtubule sort General Materials Science
Zdroj:	Applied Physics A. 75:309-313
ISSN:	1432-0630 0947-8396
DOI:	10.1007/s003390201339
Popis:	Molecular shuttles based on microtubules propelled by motor proteins can be guided on surfaces by adsorbing motors in chemical patterns or by using open guiding channels. While chemical patterns can guide microtubules based on a Brownian ratchet mechanism, the rigidity of the microtubules limits guiding to features with dimensions on the order of their persistence length (5 mm). To achieve guiding on micron-scale dimensions, physical barriers are required which can exploit the forces exerted by multiple motors to bend tubules into tight radii of curvature. Microtubule guiding is illustrated for the case of a special ratchet pattern that is capable of sorting microtubules on the basis of the direction of their motion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83bdb92118a63675dc8fefa92b1500cc https://doi.org/10.1007/s003390201339 Zobrazit plný text záznamu Plný text ve formátu PDF