Pyrazine-2-carbohydrazone of Pyridoxal 5′-Phosphate: Synthesis, Stability, Formation Kinetics, and Interaction with DNA
| Autor: | G. A. Gamov, V. V. Aleksandriyskii, M. N. Zavalishin, Valentin A. Sharnin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Pyrazine Absorption spectroscopy 010405 organic chemistry Kinetics Hydrazone General Chemistry Carbohydrazide 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Reaction rate constant chemistry Stability constants of complexes |
| Zdroj: | Russian Journal of General Chemistry. 89:230-235 |
| ISSN: | 1608-3350 1070-3632 |
| Popis: | (5-Hydroxy-6-methyl-4-{(E)-[2-oxo-2-(pyrazin-2-yl)ethyl]hydrazinylidenemethyl}pyridin-3-yl)- methyl phosphate has been synthesized via the interaction of pyridoxal-5-phosphate and pyrazin-2- carbohydrazide. Its stability constants in an aqueous solution at pH = 1.9, 6.6, 7.0, and 7.4 have been determined. The kinetics of formation and hydrolysis of the hydrazone has been studied, and rate constants of the direct and reverse reactions have been calculated from the electronic absorption spectroscopy data. The interaction of the obtained hydrazone and its Cu(II) complex with calf thymus DNA has been investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|