Prospective Evidence of a Circadian Rhythm for Out-of-Hospital Cardiac Arrests
| Autor: | Paul E. Pepe, Robert Levine, Robert E. Fromm, Peter A. Clark, Peter A. Curka |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Heart disease business.industry Period (gene) Incidence (epidemiology) Population General Medicine medicine.disease Sudden death Sudden cardiac death Internal medicine medicine Cardiology Circadian rhythm Intensive care medicine education business Prospective cohort study |
| Zdroj: | JAMA: The Journal of the American Medical Association. 267:2935 |
| ISSN: | 0098-7484 |
| Popis: | Objectives. —Published studies have indicated a circadian rhythm in the occurrence of sudden cardiac death. However, these studies have involved either retrospective analyses of death certificates or analyses of data collected during studies of pharmacologic agents in selected populations. Purpose. —To determine whether a circadian pattern could be clearly demonstrated in a prospective study of out-of-hospital sudden cardiac death in a large, unselected population. Design. —All adult cases of sudden death of presumed primary cardiac cause from a large urban population were prospectively evaluated over a 12-month period. The incidence of sudden cardiac death was analyzed using harmonic regression of the data tabulated by hour of the day. Results. —During the year of study, 1019 consecutive primary cardiac arrests were analyzed. A significant circadian pattern was found (P Conclusions. —This prospective study of out-of-hospital cardiac arrest confirms the existence of a circadian rhythm. These data have important implications for future investigations concerning the pathophysiology of sudden cardiac deaths. (JAMA. 1992;267:2935-2937) |
| Databáze: | OpenAIRE |
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