Efficacy of inactivated poliovirus vaccine in India

Autor:	Mohammad Ahmad, R. Bruce Aylward, Roland W. Sutter, Raman Sethi, Mark A. Pallansch, Concepcion F. Estivariz, Harish Verma, Abhishek Kunwar, Hamid Jafari, Arani Chatterjee, Nicholas C. Grassly, Ashutosh Agarwal, Sunil Bahl, Jagadish M. Deshpande, Shilpi Jain, Natalie A. Molodecky, Rakesh Vishwakarma
Rok vydání:	2014
Předmět:	medicine.medical_specialty Multidisciplinary biology business.industry Poliovirus medicine.disease_cause Virology law.invention Excretion Randomized controlled trial Immunity law Immunology Epidemiology biology.protein Inactivated Poliovirus Vaccine Medicine Antibody business Feces
Zdroj:	Science. 345:922-925
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1255006
Popis:	Two vaccines together are better than one alone Polio is proving difficult to eradicate. Making the choice between administering a live attenuated vaccine orally (Sabin) or an inactivated vaccine (Salk) by injection has been highly controversial. Patients prefer the Sabin vaccine, but it requires many doses to offer immunity. Jafari et al. tested the two vaccines together in northern India. The injected vaccine significantly reduced virus shedding and boosted intestinal mucosal immunity in children already given the oral vaccine. Thus, using both vaccines could help speed the eventual global demise of polio. Science , this issue p. 922
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83aa8d4be6aee41440cf0e8a9cfb9fcd https://doi.org/10.1126/science.1255006 Zobrazit plný text záznamu Plný text ve formátu PDF