Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency
Autor: | Andrew J. Carroll, Lisa M. Chelstrom, Lisa Tuel-Ahlgren, John Simon, Fatih M. Uckun, William M. Crist, Megan Ryan, Roland Gunther, James R. Downing |
---|---|
Rok vydání: | 1994 |
Předmět: |
Severe combined immunodeficiency
Ratón business.industry Immunology Chromosomal translocation Cell Biology Hematology medicine.disease Biochemistry law.invention Transplantation Leukemia law hemic and lymphatic diseases Immunopathology Acute lymphocytic leukemia Medicine business Polymerase chain reaction |
Zdroj: | Blood. 84:859-865 |
ISSN: | 1528-0020 0006-4971 |
Popis: | Mice with severe combined immunodeficiency (SCID) were injected intravenously with primary bone marrow blasts from 12 children with newly diagnosed t(4;11)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from eight patients caused overt disseminated leukemia, whereas blasts from the other four patients produced occult leukemia that was detectable only by the polymerase chain reaction (PCR) technique. Only one patient among eight whose blasts caused disseminated leukemia in SCID mice remains alive and disease-free at 48.4 months postdiagnosis. In contrast, three of the other four patients whose blasts did not cause overt leukemia in SCID mice remain alive and disease-free at 6.1, 23.6, and 35.9 months, respectively. Thus, the occurrence of overt leukemia in SCID mice may be a predictor of patients' disease-free survival. The described SCID mouse model system may prove useful for designing more effective treatment strategies against therapy- refractory t(4;11) ALL. |
Databáze: | OpenAIRE |
Externí odkaz: |