Pretransplant CD28 Biomarker (Levels of Expression and Quantification of Molecules per Cell) in Peripheral CD4+ T Cells Predicts Acute Rejection Episodes in Liver and Kidney Recipients
| Autor: | P. Ramirez, A.M. García-Alonso, M.R. Moya-Quiles, Manuel Muro, J.A. Pons, Francisco Boix, Santiago Llorente, Francisco Sánchez-Bueno, Jose Miguel Bolarín, José A. Galián, Gema Gonzalez-Martinez, Jorge Eguia, José A. Campillo, J.J. de la Peña, Isabel Legaz, Alfredo Minguela, A.M. Hernández-Martínez |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Transplantation
medicine.medical_specialty Kidney medicine.diagnostic_test medicine.medical_treatment CD28 030230 surgery Liver transplantation Biology medicine.disease Gastroenterology Flow cytometry 03 medical and health sciences Liver disease 0302 clinical medicine Cytokine medicine.anatomical_structure Internal medicine Immunology medicine Biomarker (medicine) 030211 gastroenterology & hepatology Surgery Kidney transplantation |
| Zdroj: | Transplantation Proceedings. 48:2987-2989 |
| ISSN: | 0041-1345 |
| Popis: | Background Acute rejection (AR) remains a significant cause of graft loss. Better approaches to predict AR are being investigated. Surface CD28 protein is essential for T-cell proliferation and survival as well as cytokine production. Patients and Methods Pretransplant CD4+CD28+ peripheral T cells were examined in 30 liver recipients (LRs) and 31 kidney recipients (KRs) by flow cytometry. Results Pretransplant CD4+CD28+ T cells in LRs were significantly lower in rejectors than nonrejectors (P = .002). Furthermore, the total number of CD28 molecules per cell in LRs (P = .02) as well as KRs (P = .047) was significantly lower in rejectors than nonrejectors. The healthy group did not display differences when compared with patients with end-stage liver disease or renal failure; however, stratification analysis displayed higher levels of CD4+CD28+ when compared with rejected LRs (P = .04) but not KRs. CD28 levels |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect