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Intracerebral hemorrhage results in the greatest morbidity and mortality compared to other types of stroke. Although advancements have been made in the management of intracerebral hemorrhage, currently, there is no effective treatment which improves outcomes. In order to develop treatment for intracerebral hemorrhage, efforts should be focused on better understanding of the pathophysiology of disease. In addition, consideration should be given to adapting clinical trial design to address the unique clinical challenges of this disease. These challenges include the acute nature and heterogeneity of disease, smaller number of patients compared with ischemic stroke, and difficulty in recruitment and retention, to name a few. The purpose of this chapter is to explore potential solutions to some of the challenges of designing clinical trials for patients with intracerebral hemorrhage. |
