Valeur pronostique des polyamines érythrocytaires dans le cancer du rein. Étude chez 418 patients
| Autor: | Pierre Bigot, Pierre I. Karakiewicz, Abdel-Rahmène Azzouzi, Bernard Lobel, Jean-Philippe Moulinoux, Karim Bensalah, Véronique Catros-Quemener, Giovanni Lughezzani, Francois Guille, Jean-Jacques Patard, Nathalie Rioux-Leclercq, B. Cipolla |
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| Rok vydání: | 2010 |
| Předmět: |
0303 health sciences
medicine.medical_specialty education.field_of_study Univariate analysis business.industry Urology medicine.medical_treatment Population medicine.disease Nephrectomy 3. Good health Surgery 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma 030220 oncology & carcinogenesis medicine Carcinoma T-stage Stage (cooking) Prospective cohort study education business 030304 developmental biology |
| Zdroj: | Progrès en Urologie. 20:272-278 |
| ISSN: | 1166-7087 |
| DOI: | 10.1016/j.purol.2009.10.020 |
| Popis: | OBJECTIVES: Polyamines: Spermine (Spm) and Spermidine (Spmd), are essential for cell proliferation and differentiation. A measurement of erythocytes polyamines (EPA) was developed in our institution. Our objective was to evaluate this marker as a new prognostic factor in renal cell carcinoma. PATIENTS AND METHODS: A blood sample was prospectively taken before surgery, among 418 patients who had an enlarged nephrectomy (n=318) or a partial nephrectomy (n=100) to quantify EPA rates by using the HPLC technique. The qualitative and quantitative variables have been compared using chi(2) and Student statistical analyses. The survivals have been normalized by the Kaplan Meier and Cox methods. RESULTS: The average age of our population was 64 years (21-88). The average decline was 41 months (1-214). The median size of tumors was 6.5cm (1-24). The median rate of Spm and Spmd were respectively 4.7 (1-83) and 9 (2-86)nmol/8.10(9) erythrocytes. Spm and Spmd were linked to the T stage (p=0.001), and the ECOG (p=0.001 and 0,008). Spm was not linked at N and M stages but at the Fuhrman grade (p=0.001). Spmd was linked to the N, M stages (p=0.04). With univariate analysis, the tumor diameter, the TNM stage, the Fuhrman grade as well as Spm and Spmd (p |
| Databáze: | OpenAIRE |
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