Synthesis of a new structural analogue of (+)-porothramycin

Autor:	Anne Rojas-Rousseau, Nicole Langlois
Rok vydání:	2001
Předmět:	Circular dichroism chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Diastereomer Horner–Wadsworth–Emmons reaction Cytotoxicity Biochemistry Phosphonate
Zdroj:	Tetrahedron. 57:3389-3395
ISSN:	0040-4020
Popis:	A new phosphonate analogue of (+)-porothramycin has been synthesized from (S)-pyroglutaminol. Circular dichroism of diastereomeric intermediates 9 has been studied. The cytostatic activity of the new pyrrolo[2,1-c][1,4]benzodiazepine has been evaluated against human KB cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::839d0322103e65dde9ee4909cbcbc70a https://doi.org/10.1016/s0040-4020(01)00197-1 Zobrazit plný text záznamu Full Text from ScienceDirect