PS1:4 Searching biomarkers in lupus nephritis by proteomics
| Autor: | F. Elortza, M. Azkargorta, N. Rivera Garcia, J.M. Blanco Madrigal, I. Torre Salaberri, E. Ucar, E. Galindez Agirregoikoa, ME Ruiz Lucea, O. Fernández Berrizbeitia, M. L. García Vivar, C. E. Pérez Velásquez |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Systemic lupus erythematosus medicine.diagnostic_test business.industry Lupus nephritis Glomerulonephritis medicine.disease Proteomics Gastroenterology Nephropathy Internal medicine medicine In patient Renal biopsy Protein pattern skin and connective tissue diseases business |
| Zdroj: | Poster session 1: Autoantibodies, biomarkers and imaging (1). |
| DOI: | 10.1136/lupus-2018-abstract.53 |
| Popis: | Introduction Lupus nephropathy (NL) is an important cause of morbidity and mortality in patients with SLE. The objective of the renal biopsy is to determine the type of glomerulonephritis that the patient presents to be treated. A proteomics study is proposed to determine biomarkers that help us to differentiate patients diagnosed with SLE with and without renal involvement. Objective To determine if there are a different patron of proteins between patients diagnosed with SLE with and without renal involvement. Methods We selected 12 patients diagnosed with SLE with renal involvement and 14 patients diagnosed with SLE without renal involvement. A 24 hour urine sample was obtained for analysis. Results A total of 292 proteins (identified with at least two peptides with a FDR Conclusion A different protein pattern is observed between the two groups of patients, so in a more detailed study we can indicate if some of these can serve as prognostic markers for this type of patients. |
| Databáze: | OpenAIRE |
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