Synthesis, characterization, crystal structure and antiproliferative in vitro activity of long-chain aliphatic thiosemicarbazones and their Ni(II) complexes

Autor:	Pieralberto Tarasconi, Silvana Pinelli, Franco Bisceglie, Giorgio Pelosi, Marisa Belicchi-Ferrari
Rok vydání:	2007
Předmět:	U937 cell Stereochemistry Cell growth chemistry.chemical_element Biological activity In vitro Heptanal Inorganic Chemistry NMR spectra database chemistry.chemical_compound Nickel chemistry hemic and lymphatic diseases Materials Chemistry Physical and Theoretical Chemistry Semicarbazone
Zdroj:	Polyhedron. 26:5150-5161
ISSN:	0277-5387
DOI:	10.1016/j.poly.2007.07.014
Popis:	In the course of a research on metal-based compounds active on white blood cell cancers (leukemia, lymphoma and myeloma) nine aliphatic thiosemicarbazones and their nickel complexes have been synthesized with the aim to test their effect on histiocytic lymphoma U937 cell proliferation. All compounds were characterized by elemental, IR and NMR spectra analyses and for five of the complexes also by X-ray crystallography diffraction analysis. Heptanal thiosemicarbazone and the corresponding nickel complex were chosen after a solubility/stability test to carry out preliminary experiments in vitro on human leukemia cell line U937. The complex possesses a remarkable biological activity in inhibiting cell growth and in inducing apoptosis.
Databáze:	OpenAIRE
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