Extended versus standard lymphadenectomy in patients undergoing pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective randomized single center trial
| Autor: | Jan E. Slotta, J. Sperling, Otto Kollmar, Jochen Schuld, A. M. Hechler |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment fungi 030230 surgery Vascular surgery Pancreaticoduodenectomy Single Center Cardiac surgery Surgery 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Periampullary Adenocarcinoma 030220 oncology & carcinogenesis medicine Lymphadenectomy business Lymph node Abdominal surgery |
| Zdroj: | European Surgery. 48:26-33 |
| ISSN: | 1682-4016 1682-8631 |
| Popis: | Although randomized studies investigated the benefit of extended lymphadenectomy (ELA) compared to standard lymphadenectomy (SLA) for periampullary adenocarcinoma, these analyses failed to show overall advantage for ELA due to high heterogeneity of lymphadenectomy protocols. Therefore, the present single-center trial was designed using a standardized protocol for SLA with en bloc technique. Patients undergoing pancreaticoduodenectomy for periampullary adenocarcinoma were randomized to either SLA or ELA. Primary study endpoint was recurrence-free survival. Secondary endpoints were overall survival as well as peri- and postoperative morbidity and mortality. Sixty-six out of 103 randomized patients were treated by SLA (n = 34) or ELA (n = 32) and included into final data analysis. ELA compared to SLA resulted in a higher number of removed lymph nodes (25 ± 12 vs. 14 ± 8; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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