Oral Mucositis in Patients with Hematologic Malignancies Undergoing Chemotherapy
| Autor: | Renata Portela de Rezende, Davi Silva Carvalho Curi, Patricia Miranda Leite-Ribeiro, Thaiane Dantas Dias dos Santos, Liliane Lins-Kusterer, Viviane Almeida Sarmento |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Melphalan medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Cryotherapy Hematopoietic stem cell transplantation medicine.disease Chemotherapy regimen medicine.anatomical_structure Internal medicine medicine Mucositis Methotrexate Oral mucosa business medicine.drug |
| Zdroj: | SN Comprehensive Clinical Medicine. 3:2149-2153 |
| ISSN: | 2523-8973 |
| DOI: | 10.1007/s42399-021-01000-4 |
| Popis: | The aim of this study was to evaluate the frequency of oral mucositis in patients with hematologic malignancies and relating to the cancer treatment and chemotherapy regimen. This was a cross-sectional study with 112 patients with hematologic malignancies treated by chemotherapy. The association between oral mucositis and the variables was performed by Pearson’s chi-square test, considering a 5% error probability. The frequency of oral mucositis was low (25%). Its occurrence was associated with hematopoietic stem cell transplantation (PR = 3.33, 95% CI = 1.60–6.91) and the use of melphalan or methotrexate (PR = 5.26, 95% CI = 2.31–11.95). Some chemotherapy drugs, such as melphalan and methotrexate, are more toxic to the oral mucosa, as well as the chemotherapy regimen prior to hematopoietic stem cell transplantation. Furthermore, the low frequency of oral mucositis may be related to preventive non-pharmacological protocols, like cryotherapy during drug infusion and laser therapy. This result suggests the importance of the oral care to patients with hematologic malignancies undergoing chemotherapy. |
| Databáze: | OpenAIRE |
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