Reduced Nitric Oxide Bioavailability in Horses with Colic: Evaluation by ESR Spectroscopy
| Autor: | M. Kovac, M. I. Kuznetsova, Anatoly F. Vanin, Vladimir A. Serezhenkov, Z. S. Artyushina, N. A. Tkachev |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gastrointestinal tract medicine.medical_specialty 030102 biochemistry & molecular biology biology Biophysics Inflammation biology.organism_classification medicine.disease_cause Bioavailability Nitric oxide Caecum 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Blood serum Endocrinology chemistry Internal medicine medicine medicine.symptom Nitrite Oxidative stress |
| Zdroj: | Biophysics. 65:869-875 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350920050176 |
| Popis: | The pathogenesis of diseases of the gastrointestinal tract in horses is accompanied by inflammation and oxidative stress and may be caused by a lack of nitric oxide, which controls various signaling pathways in the body. The level of nitrites, which are metabolites of nitric oxide in horses with various intestinal diseases, has been evaluated in blood serum at 3.60 ± 3.02 μM and 8.3 ± 6.0 μM in horses at ages of 7–26 years and 1–5 years, respectively. A sharp reduction in the nitrite concentrations was observed in all horses with intestinal diseases (3.39 ± 2.85 μM), especially in horses with tympanitic caecum (0.6 ± 0.4 μM) and obstruction of the colon (0.81 ± 0.5 μM). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink