Minireview
| Autor: | Sarasin A, Le Page F, Gentil A |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Biological Chemistry. 378 |
| ISSN: | 1437-4315 1431-6730 |
| DOI: | 10.1515/bchm.1997.378.11.1287 |
| Popis: | The consequence of translesional replication of unique UV-induced photoproducts is reviewed here. Mutagenesis induced by unique UV-induced lesions, the thymine-thymine dimer (TT) and the thymine-thymine pyrimidine pyrimidone (6-4), [T(6-4)T] carried on single-stranded DNA vectors and replicated in bacteria, yeast and mammalian cells have been considered. It has been found that in all of the three species the (TT) dimers induce a low mutation frequency compared to the (6-4) photoproduct. The molecular analysis of the mutations induced is reported, showing specific differences depending on the species considered. |
| Databáze: | OpenAIRE |
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