| Autor: |
Ram Chand Dhakar, P. Kaliraj, G. Pandiarajan, T. Loganathan, R. Jayakumararaj, S. Ramya, B. Mathialagan, N. Senthilkumar, C. Kandeepan, GA. Pallan, AN. Basha, RV. Kalaimathi, M. Murugan, K. Krishnaveni |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery and Therapeutics. 12:132-145 |
| ISSN: |
2250-1177 |
| Popis: |
Palmitic Acid (PA) is known to exert multiple fundamental biological functions at cellular and tissue levels and its steady concentration is guaranteed by its endogenous synthesis by DNL. PA has been for a long time negatively represented for its detrimental health effects tailing its essential physiological attributes. PA has been portrayed to serve as a signalling molecule regulating the progression and development of many diseases at molecular level. Controversial data on the association of dietary PA with detrimental health effects has been related to several parameters such as fatty acid/ macronutrient imbalance by altered lipid metabolism, positive energy balance, excessive intake of carbohydrates, imbalance of dietary PA/PUFA, physiopathological conditions, presence of enhanced DNL and sedentary lifestyle. This may result in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone indicating that clear understanding of system based PA metabolism is still lacking. In the present study an attempt has been made to bring out the absorption, distribution, metabolism, elimination and toxicity profile of PA. Results are expected to have some implications in elucidating the molecular mechanisms that regulates pathophysiological events involved in hyperglycemia/ hyperlipidemia-induced complications associated with diabesity and CVD. Besides it may provide a better understanding to identify key molecular targets for therapeutic management of PA induced metabolic disorders. Keywords: Moringa oleifera; MOLE; Bioactive Secondary Metabolites; ADME/Tox; Natural Products (NPs); PBNPs; PDHA; n-Hexadecanoic Acid (nHDA); Palmitic Acid (PA) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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