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Purpose:Non-ischemic Functional Mitral Regurgitation (FMR) is accompanied by dire long-term consequences. The treatment revolves around correcting the underlying LV dysfunction. This study reports long-term follow-up outcomes and prognosis predictors of non-ischemic FMR.Methods:We enrolled 200 patients with at-least-moderate non-ischemic FMR, undergoing medical treatment and/or cardiac resynchronization therapy (CRT) between 2003 and 2019. MR severity and LV dysfunction parameters were obtained. The endpoint outcomes were all-cause mortality, stroke, all-cause rehospitalization, and the need for heart transplantation.Results:Two hundred participants, 104 (52%) men and 96 (48%) women with the median age of 61 years (IQR 50-70) at diagnosis and the median follow-up of 2 years (IQR 1-4), were enrolled. The all-cause mortality, all-cause rehospitalization, and need for heart transplantation were significantly associated with lower LVEF and TAPSE at diagnosis (P-valueConclusion: We detected a significant decline in MR severity and NYHA classification during follow-up. Overall, the FMR-associated mortality risk will be significantly reduced by closely sticking to the treatment guidelines in a tertiary heart center. |
