Positive Selection of Mutations in the Helicobacter pylori katA 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease

Autor:	John T. Loh, Jennifer H. B. Shuman, Aung Soe Lin, Natalie Favret, M. Blanca Piazuelo, Simon Mallal, Abha Chopra, Mark S. McClain, Timothy L. Cover
Rok vydání:	2022
Předmět:	Infectious Diseases Immunology Parasitology Microbiology
Zdroj:	Infection and Immunity. 90
ISSN:	1098-5522 0019-9567
Popis:	To evaluate potential effects of gastric inflammation on Helicobacter pylori diversification and evolution within the stomach, we experimentally infected Mongolian gerbils with an H. pylori strain in which Cag type IV secretion system (T4SS) activity is controlled by a TetR/ tetO system. Gerbils infected with H. pylori under conditions in which Cag T4SS activity was derepressed had significantly higher levels of gastric inflammation than gerbils infected under conditions with repressed Cag T4SS activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83791eb78cf08cf88f155ee5e15c9458 https://doi.org/10.1128/iai.00004-22 Zobrazit plný text záznamu