NaYbF4nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration in photodynamic therapy
| Autor: | N. Z. Zhong, Jianru Xiao, Haichun Li, Pengxiang Wang, G. C. Jiang, Wenwu Cao, D. J. Jiang, Zhen Zhang, D. X. Ban, S. Chen, Junshuai Zhang, Zheng Hu |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Infrared medicine.medical_treatment Near-infrared spectroscopy technology industry and agriculture Nanoparticle Photodynamic therapy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences 0104 chemical sciences Excited state medicine General Materials Science Photosensitizer 0210 nano-technology Penetration depth Visible spectrum |
| Zdroj: | Nanoscale. 9:2706-2710 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c6nr09401e |
| Popis: | Photodynamic therapy (PDT) is a non-invasive therapy with many advantages over other therapeutic methods, but it is restricted to treat superficial cancers due to the shallow tissue penetration of visible light. The biological window in the near infrared region (NIR) offers hope to extend the penetration depth, but there is no natural NIR excited photosensitizer. Here, we report a novel photosensitizer: NaYbF4 nanoparticles (NPs). By using a 1,3-diphenylisobenzofuran (DPBF) sensor, we show that the Yb3+ ions can absorb the NIR light and transfer energy directly to oxygen to generate reactive oxygen species (ROS). The efficiency of transferring energy to oxygen by NaYbF4 NPs is comparable to that of traditional photosensitizers. We have carried out PDT both in vitro and in vivo based on NaYbF4 NPs; the results demonstrate that NaYbF4 NPs are indeed an effective NIR photosensitizer, which can help extend the application of PDT to solid tumors owing to the much deeper penetration depth of NIR light. |
| Databáze: | OpenAIRE |
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