Non-linear Multiphysic Numerical Study of Bone Tumor Hyperthermia Using Magnetic Biomaterials
| Autor: | Matteo Bruno Lodi, Giuliano Vacca, Giuseppe Mazzarella, Alessandro Fanti, Giacomo Muntoni |
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| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
Hyperthermia Electromagnetic wave equation Materials science Finite element software Quantitative Biology::Tissues and Organs Physics::Medical Physics Hyperthermia Treatment 02 engineering and technology Osteosarcoma Tumor medicine.disease 01 natural sciences Quantitative Biology::Cell Behavior Magnetic field Nonlinear system 020401 chemical engineering 0103 physical sciences medicine Magnetic nanoparticles 0204 chemical engineering human activities Biomedical engineering |
| Zdroj: | 2019 IEEE MTT-S International Conference on Numerical Electromagnetic and Multiphysics Modeling and Optimization (NEMO). |
| DOI: | 10.1109/nemo.2019.8853664 |
| Popis: | This work deals with the non-linear and multiphysic modeling of the hyperthermia treatment of bone tumors using novel biomaterials loaded with magnetic nanoparticles. The possible treatment of Osteosarcoma tumor with magnetic hydroxyapatite and poly-caprolactone doped with magnetite nanoparticles are analyzed. During the procedure, the materials and tissue physical properties modifies due to the heating, implying a coupled solution of thermal and electromagnetic equations. In the present study a numerical model, implemented using a commercial finite element software, is developed to include the intrinsic non-linearities of the hyperthermia multiphysic treatment. Therefore, an accurate in silico analysis is performed to identify the strength and frequency of the external magnetic field which would ensure an effective therapy, evaluated using the thermal dose damage analysis. |
| Databáze: | OpenAIRE |
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