ChemInform Abstract: Bis(S-acyl-2-thioethyl)esters of 2′,3′-Dideoxyadenosine 5′- Monophosphate Are Potent Anti-HIV Agents in Cell Culture

Autor:	H. Pelicano, Jean Louis Imbach, André Kirn, Jean-Luc Girardet, Christian Périgaud, S. Benzaria, Anne-Marie Aubertin, Gilles Gosselin, Georges Maury
Rok vydání:	2010
Předmět:	Dideoxyadenosine chemistry.chemical_compound chemistry Stereochemistry Anti hiv Nucleic acid General Medicine Nucleoside Derivative (chemistry) Orders of magnitude (mass)
Zdroj:	ChemInform. 26
ISSN:	0931-7597
Popis:	It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::836dd1e907d64c91038a76b2c6eb3c3c https://doi.org/10.1002/chin.199539255 Zobrazit plný text záznamu Plný text