Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells
| Autor: | Girts Salms, Aleksandrs Grisulonoks, Andrejs Skagers, Vadims Klimecs, Arnis Abolins, Janis Locs, Ilze Šalma, Inese Cakstina |
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| Rok vydání: | 2016 |
| Předmět: |
Bone mineral
medicine.medical_specialty Materials science Mechanical Engineering Osteoporosis Cell Mesenchymal stem cell 030209 endocrinology & metabolism 030206 dentistry medicine.disease Bone tissue Transplantation 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Mechanics of Materials Internal medicine medicine General Materials Science Stem cell Bone regeneration |
| Zdroj: | Key Engineering Materials. 721:240-244 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.721.240 |
| Popis: | To target areas of the skeletal system which are clinically significant sites is a new strategy as the"local treatment of osteoporosis". Synthetic bioceramics implanted into critical sized bone defect of rats with experimental osteoporosis demonstrateds better effect to bone tissue repair in osteoporosis and/or osteoporosis status. Stem cell transplantation may improve bone mineral density in animal models of osteoporosis. An adequate blood supply of mesenchymal cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The concentration and quality of MSCs may vary significantly, depending on the individual (especially in older people), the cell obtaining sites and techniques used. Combination of BCP and stem cells are not studied on old experimental animals with double induced osteoporosis. |
| Databáze: | OpenAIRE |
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