Abstract P010: D 1 R And D 5 R And Their Role In The Etiology Of Inverse Salt Sensitivity Of Blood Pressure

Autor:	Peng Xu, John J Gildea, Pedro A. Jose, Robert M. Carey, Wei Yue, Michael G Daley, Katherine Schiermeyer, Robin A. Felder
Rok vydání:	2020
Předmět:	chemistry.chemical_classification medicine.medical_specialty Chemistry food.diet Incidence (epidemiology) Salt (chemistry) Low sodium diet Angiotensin II Blood pressure food Endocrinology Internal medicine Salt sensitivity Internal Medicine medicine Etiology
Zdroj:	Hypertension. 76
ISSN:	1524-4563 0194-911X
DOI:	10.1161/hyp.76.suppl_1.p010
Popis:	Cardiovascular studies show increased morbidity and mortality in individuals consuming low sodium diets as well as high salt diets. The incidence of salt sensitivity of blood pressure (SS) in normotensives is approximately 18%, causing similar mortality and morbidity as hypertensives. Paradoxically, approximately 15% of normotensives demonstrate an increase in blood pressure on low sodium diets, known as inverse salt sensitivity (ISS). However, little is known about the morbidity and mortality associated with ISS, let alone the mechanisms behind this condition. Since dopamine regulates up to 75% of renal sodium handling, we hypothesized that the dopamine 1 and 5 receptors (D1R, D5R) were involved with the etiology of ISS. Using renal proximal tubule cells (RPTC) isolated from salt diet participant’s urine exposed to 90 mM salt (NaCl) (2 hr), we demonstrated reduced binding of the non-cell permeable D1-like antagonist (D1R and D5R) bodipy-530 SKF83566 (Fl-SKF) in the ISS RPTC when compared to salt resistant (SR) RPTC (ISS -13.9 ± 3.8% vs SR -1.1 ± 3.2%, n=12, p
Databáze:	OpenAIRE
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