Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates

Autor:	V. V. R. M. Krishna Reddy, K. Kishore Babu, G. Madhusudhan, Khagga Mukkanti, P. Srinivasulu, A. Ganesh
Rok vydání:	2010
Předmět:	Chemistry Impurity Scientific method Organic Chemistry Moiety Physical and Theoretical Chemistry Related impurities High yielding Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 14:931-935
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op100100y
Popis:	An improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatography-free with purity 99.3 area %.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::836007b278eb45b3fcea8ebfb073ccd1 https://doi.org/10.1021/op100100y Zobrazit plný text záznamu