The UCLA population studies of chronic obstructive respiratory disease
| Autor: | Roger Detels, Donald P. Tashkin, Anne H. Coulson, James Sayre, Stanley N. Rokaw |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Spirometry
medicine.medical_specialty education.field_of_study medicine.diagnostic_test business.industry Population Respiratory disease Disease classification Reference laboratory medicine.disease Biochemistry FEV1/FVC ratio Internal medicine Physical therapy medicine Plethysmograph business education Reliability (statistics) General Environmental Science |
| Zdroj: | Environmental Research. 20:403-424 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/0013-9351(79)90016-1 |
| Popis: | A probability sample of 218 adults tested at a mobile lung function (field) laboratory was retested at a UCLA reference laboratory. Results in the two laboratories were compared for (i) numerical correlation, (ii) variability, and (iii) agreement in disease classification. FEV 1 and FVC showed good agreement between laboratories. Plethysmography showed good agreement and moderate correlation. SBNT showed poor correlation, high variability, but good agreement. Test subjects were classified by two respiratory specialists as having or not having chronic obstructive respiratory disease. Individuals thus diagnosed were considered to be true positives and the results of each of the tests, groups of tests, and all tests in each laboratory were evaluated, using these criteria, for their estimated sensitivity and specificity: (i) FEV 1 , FVC , and plethysmography were estimated to be specific but relatively insensitive; (ii) FEF 25–75% was less specific but more sensitive; (iii) the flow-volume curve had the highest sensitivity and reasonable specificity; (iv) closing volume showed reasonable sensitivity and specificity but was not reliable. Determination of specificity may have been confounded by the presence of disease too early to diagnose clinically. The disparity in classification between the two laboratories was no greater than that between the two physicians. Field screening using spirometry, SBNT, and body plethysmography is apparently comparable to comprehensive diagnostic procedures in a clinic setting. |
| Databáze: | OpenAIRE |
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