Gene analysis of retrograde degeneration
| Autor: | Toshihiko Miyake, Yoshinari Gahara, Hajime Yamada, Ken-Ichiro Uwabe, Tadahisa Kitamura |
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| Rok vydání: | 1997 |
| Předmět: |
Nervous system
Retrograde Degeneration medicine.medical_treatment Regeneration (biology) Neurodegeneration General Medicine Degeneration (medical) Neuropathology Anatomy Biology medicine.disease Pathology and Forensic Medicine medicine.anatomical_structure Gene expression medicine Neurology (clinical) Axotomy Neuroscience |
| Zdroj: | Neuropathology. 17:145-151 |
| ISSN: | 1440-1789 0919-6544 |
| Popis: | Retrograde degeneration of neurons following axotomy is an excellent experimental model of neurodegeneration. Using this model, molecular biological techniques have demonstrated a number of specific genes to be involved in the pathological processes of degeneration, regeneration, and repair which occur after axotomy. Further insight into gene involvement in these processes can be gained using the recently developed methods for screening genes whose expression is up- or down-regulated after injury. These methods have successfully identified many genes to be markedly regulated and thus significantly involved in retrograde degeneration of the rat facial nucleus after axotomy of the facial nerve. Some are novel genes not previously identified, and others are genes already documented but their involvement in neuropathology not previously evaluated. Elucidation of the function of these genes would aid studies on the pathology of retrograde degeneration and provide important information on degenerative disorders of the human nervous system. |
| Databáze: | OpenAIRE |
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