Diagnostic value of FDG-PET/CT in the diagnostic work-up of inflammation of unknown origin
| Autor: | Luisa Maria Knappe, Frederik Anton Verburg, Luca Giovanella, Markus Luster, Damiano Librizzi |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Nuklearmedizin - NuclearMedicine. 62:27-33 |
| ISSN: | 2567-6407 0029-5566 |
| DOI: | 10.1055/a-1976-1765 |
| Popis: | Introduction The present study aims to evaluate the clinical diagnostic value of FDG-PET/CT in patients with inflammation of unknown origin. Material and methods We retrospectively analyzed data of 130 patients who presented general inflammatory symptoms and/or elevated level of CRP and underwent FDG-PET/CT for the purpose of identifying unknown foci of inflammation. The accuracy of PET/CT findings was assessed against the standard of eventual clinical diagnosis e.g. results of pathology, microbiology or other imaging methods. Results In 99/130 patients (76 %) a final diagnosis was established, FDG-PET/CT showed a sensitivity and specificity of each 93 %. A decreased pseudocholinesterase is associated with a higher SUVmax value and with a higher CRP value whereas no significant relationship was found between elevated CRP values and the SUVmax, although higher CRP values are associated significantly with a true positive PET/CT result. Conclusion FDG-PET/CT is a highly sensitive, specific and accurate method for the detection of foci of inflammation of unknown origin. The combination of decreased pseudocholinesterase and increased CRP levels may be a useful tool to select patients for FDG PET/CT. |
| Databáze: | OpenAIRE |
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