A PHARMACOLOGICAL STUDY ON THE ANTI-INFLAMMATORY EFFECTS OF CALENDULA OFFICINALIS EXTRACT ON EXPERIMENTAL ANIMALS

Autor:	Ranjeet Kumar, Sarju R. Zilate, Sweety Kumari, Sushil Kumar Varma
Rok vydání:	2019
Předmět:	biology Traditional medicine medicine.drug_class Anti inflammation Biological activity biology.organism_classification medicine.disease Anti-inflammatory Carrageenan chemistry.chemical_compound chemistry Calendula officinalis Granuloma medicine Calendula officinalis extract Paw edema
Zdroj:	Journal of Biomedical and Pharmaceutical Research. 8
ISSN:	2279-0594 2589-8752
DOI:	10.32553/jbpr.v8i2.591
Popis:	Introduction: Calendula officinalis is one of those plants which have medicinal importance due to its flowers has pharmacological activity the important pharmacological parameters have been less investigated properly and can be scientifically proved by reverse pharmacology. It was found of interest to evaluate these properties of extract of flowers of Calendula officinalis scientifically in experimental models. Methods: Study was conducted in Albino Wistar rats.Fresh Calendula officinalis flowers were collected, extraction and drug formulation was made. Anti-inflammatory activity of hydroalcoholic extract of Calendula officinalis (HECO) flowers was studied in the Carrageenan induced paw edema model & Cotton pellet induced granuloma models The differences between experimental groups were compared by ANOVA followed by Students “t” unpaired test. Results: The Calendula officinalis extract of flowers at 200 and 400 mg/kg showed significant and highly significant inhibition (p< 0.05 and p
Databáze:	OpenAIRE
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