Dissection and Aneurysm in Patients With Fibromuscular Dysplasia
| Autor: | Aditya Sharma, Esther S.H. Kim, Christopher J. White, Michael R. Jaff, Heather L. Gornik, Bruce H. Gray, Pamela Mace, Yung-Wei Chi, Jeffrey W. Olin, J. Michael Bacharach, Daniella Kadian-Dodov, Xiaokui Gu, James B. Froehlich, Eva Kline-Rogers |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Dissection (medical) Fibromuscular dysplasia 030204 cardiovascular system & hematology medicine.disease Magnetic resonance angiography Surgery Coronary arteries 03 medical and health sciences Stenosis 0302 clinical medicine medicine.anatomical_structure Aneurysm Angiography cardiovascular system medicine cardiovascular diseases Radiology Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Computed tomography angiography |
| Zdroj: | Journal of the American College of Cardiology. 68:176-185 |
| ISSN: | 0735-1097 |
| Popis: | Background Fibromuscular dysplasia (FMD) is a noninflammatory arterial disease that predominantly affects women. The arterial manifestations may include beading, stenosis, aneurysm, dissection, or tortuosity. Objectives This study compared the frequency, location, and outcomes of FMD patients with aneurysm and/or dissection to those of patients without. Methods The U.S. Registry for FMD involves 12 clinical centers. This analysis included clinical history, diagnostic, and therapeutic procedure results for 921 FMD patients enrolled in the registry as of October 17, 2014. Results Aneurysm occurred in 200 patients (21.7%) and dissection in 237 patients (25.7%); in total, 384 patients (41.7%) had an aneurysm and/or a dissection by the time of FMD diagnosis. The extracranial carotid, renal, and intracranial arteries were the most common sites of aneurysm; dissection most often occurred in the extracranial carotid, vertebral, renal, and coronary arteries. FMD patients with dissection were younger at presentation (48.4 vs. 53.5 years of age, respectively; p Conclusions Patients with FMD have a high prevalence of aneurysm and/or dissection prior to or at the time of FMD diagnosis. Patients with dissection were more likely to experience ischemic events, and a significant number of patients with dissection or aneurysm underwent therapeutic procedures for these vascular events. Because of the high prevalence and associated morbidity in patients with FMD who have an aneurysm and/or dissection, it is recommended that every patient with FMD undergo one-time cross-sectional imaging from head to pelvis with computed tomographic angiography or magnetic resonance angiography. |
| Databáze: | OpenAIRE |
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