Novel options in Prenatal Genetic Diagnostic

Autor:	Tatyana V. Kuznetzova, Vladislav S Baranov
Rok vydání:	2015
Předmět:	Genetics Array-Based Comparative Genomic Hybridization medicine.diagnostic_test business.industry State of art Obstetrics and Gynecology Medicine Routine clinical practice Computational biology business Genetic testing
Zdroj:	Journal of obstetrics and women's diseases. 64:4-12
ISSN:	1683-9366 1684-0461
DOI:	10.17816/jowd6424-12
Popis:	Modern molecular approaches to prenatal diagnostic of inherited diseases are briefly reviewed. Advantages and limitations of molecular methods for analysis of chromosomal anomalies (QF-PCR, aCGH, NGS) are considered in line with conventional prenatal karyotyping. The special attention is paid to efficacy, limitations and diagnostic options of noninvasive prenatal genetic testing (NIPT). Some particular problems of its widespread implication into routine clinical practice are discussed. State of art in preimplantation genetic diagnostics (PGD) and obvious great opportunities of preconceptional genetic testing are highlighted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83202d1ca53c3c73b9d12417cfbe48a5 https://doi.org/10.17816/jowd6424-12 Zobrazit plný text záznamu