The effect of erythrocyte stimulating agents on mean platelet volume, the platelet/lymphocyte ratio and the neutrophil/lymphocyte ratio in children with chronic kidney disease
| Autor: | Fehime Kara Eroglu, Gökçe Can, Evrim Kargın Çakıcı, Mehmet Bülbül, Tülin Güngör, Evra Çelikkaya, Fatma Yazılıtaş |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Thrombocytosis business.industry medicine.medical_treatment General Medicine medicine.disease Gastroenterology Peritoneal dialysis Psychiatry and Mental health Neuropsychology and Physiological Psychology Internal medicine medicine Absolute neutrophil count Platelet Hemodialysis Mean platelet volume business Dialysis Kidney disease |
| Zdroj: | Ortadoğu Tıp Dergisi. 11:193-199 |
| ISSN: | 2548-0251 1309-3630 |
| DOI: | 10.21601/ortadogutipdergisi.417743 |
| Popis: | Aim: Chronic kidney disease is associated with some hematologic changes such as decreased platelet production, platelet dysfunction and thrombocytosis. The inflammatory markers increase in chronic kidney disease. Mean platelet volume, the ratio of neutrophil count to lymphocyte count, and the ratio of platelet count to lymphocyte count are indicative of inflammation. Erythrocyte stimulating agents can increase platelet count and thrombotic events. We aimed to determine the relationship between the use of erythrocyte stimulating agents and mean platelet volume, the neutrophil/lymphocyte ratio and the platelet/lymphocyte ratio in children with chronic kidney disease in this study. Material and Method: The files of 30 patients diagnosed with chronic kidney disease and treated with erythrocyte stimulating agents between 2013 and 2018 were reviewed retrospectively. Results: The mean age of the patients (16 boys and 14 girls) was 10.6 ± 5.4 years (median 12; 1-17 years). Twelve of them were in pre-dialysis, 9 in hemodialysis and 9 in peritoneal dialysis group. The mean duration of use of erythrocyte stimulating agents was 29.2 ± 34.8 months (median 12.5; 1-127 months). Mean platelet volume values after treatment with erythrocyte stimulating agents in chronic kidney disease patients were significantly higher in all groups. The platelet/lymphocyte ratio values after treatment with erythrocyte stimulating agents were not significant different in all groups. The platelet/lymphocyte ratio had a significant but opposite correlation with mean platelet volume, white cell count and monocyte counts. Mean platelet volume and the neutrophil/lymphocyte ratio measurements were affected by dialysis modality. However the platelet/lymphocyte ratio was not affected. Conclusions: In this small retrospective study, we could not report causality and effect associations in our results. Nevertheless, these simple, cheap, universal methods may be used as the first step in the evaluation of patients by nephrologists. |
| Databáze: | OpenAIRE |
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