8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE2 antagonist and analgesic
| Autor: | Awilda Stapelfeld, Melvin Reichman, M. A. Savage, E. Ann Hallinan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Carboxylic acid Organic Chemistry Clinical Biochemistry Analgesic Antagonist Pharmaceutical Science Thio Hydrazide Biochemistry chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine Oxazepine Prostaglandin E2 Molecular Biology ED50 medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:509-514 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(94)80027-8 |
| Popis: | SC-51322 is the most potent PGE2 antagonist (pA2 = 8.1) and analgesic (ED50 = 0.9 mg/kg) that has been seen in this series of N-substituted dibenzoxazepines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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