Hypercoagulability in the Context of Pre-Eclampsia: Case-Control Study at the Laquintinie Douala Hospital (Cameroon)
| Autor: | Grégory Eddie Halle, Pascal Foumane, Theophile Nana Njamen, Grace Tocki Toutou, Merlin Boten, Guy Pascal Ngaba, Marie Solange Ndom Idjem, Thomas Egbe Obinchemti, Henri Essome |
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| Rok vydání: | 2020 |
| Předmět: |
Pregnancy
medicine.medical_specialty Eclampsia Obstetrics business.industry Prothrombin level Case-control study Gestational age medicine.disease female genital diseases and pregnancy complications Preeclampsia embryonic structures medicine Amenorrhea medicine.symptom business Body mass index reproductive and urinary physiology |
| Zdroj: | Open Journal of Obstetrics and Gynecology. 10:1708-1727 |
| ISSN: | 2160-8806 2160-8792 |
| DOI: | 10.4236/ojog.2020.10120155 |
| Popis: | Introduction: Preeclampsia is one of the major causes of maternal and neonatal morbidity and mortality in the world. The complexity of its etio-pathogenesis involves, among other things, hypercoagulability, which alone accounts for about 15% of his deaths. Our objective was to study the parameters of coagulation (prothrombin level, activated cephalin time) in pregnant women with preeclampsia and non-preeclampsia at Laquintinie Hospital in Douala. Methodology: We carried out an analytical cross-sectional case-control study from November 01st, 2018 to May 31st, 2019, in the gynecology and obstetrics department of Laquintinie Hospital in Douala. We included preeclampsia and non-preeclampsia pregnant women with a gestational age greater than or equal to 20 weeks amenorrhea. The variables of interest were age, pregnancy, parity, gestational age, marital status and body mass index, prothrombin level (PL) and activated cephalin time (ACT). Hypercoagulability was defined by the presence of at least one of the following abnormalities: PL > 100%, ACT 25 seconds. Statistical tests were considered significant for a p-value 0.05. Results: We recruited 150 pregnant women including 50 preeclampsia matched with 100 non-preeclampsia. The majority age group in both groups was 25 - 30 years (32% versus 37%). We found a high PL in 58% of preeclampsia versus 22% of non-preeclampsia patients (p = - 10.20; p = Conclusion: Our study confirms the existence of hypercoagulability associated with preeclampsia, in particular in relation to an increase in the level of prothrombin. |
| Databáze: | OpenAIRE |
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