Synthesis of 6-R-6,7-dihydro-3H,5H-[1,2,4]dithiazolo[4,3-a][1,3,5]triazine-3-thiones by aminomethylation of xanthane hydride

Autor:	Tatyana Evmeshenko, Gennady D. Krapivin, Victor V. Dotsenko
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Primary (chemistry) 1 3 5-Triazine Chemistry Xanthane hydride Medicinal chemistry Mannich reaction Triazine
Zdroj:	Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry.
DOI:	10.3390/ecsoc-20-a064
Popis:	Xanthane hydride (5-Amino-3H-1,2,4-dithiazole-3-thione) reacts with primary amines (1 eq.) and HCHO (2 eq.) under harsh conditions (reflux in DMSO) to give a hitherto unknown heterocyclic system, 6,7-dihydro-3H,5H-[1,2,4]dithiazolo[4,3-a][1,3,5]triazine. The products were confirmed by NMR studies.
Databáze:	OpenAIRE
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