Regulation of Anti-Müllerian Hormone Production in the Cow: A Multiscale Study at Endocrine, Ovarian, Follicular, and Granulosa Cell Levels1
| Autor: | Martine Bontoux, Claire Médigue, Danielle Monniaux, Peggy Jarrier, Stéphane Fabre, Charlène Rico, Frédérique Clément |
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| Rok vydání: | 2011 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Granulosa cell media_common.quotation_subject Ovary Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Follicular phase medicine Ovarian follicle Ovulation 030304 developmental biology media_common 2. Zero hunger Estrous cycle 0303 health sciences 030219 obstetrics & reproductive medicine urogenital system Anti-Müllerian hormone Cell Biology General Medicine female genital diseases and pregnancy complications Embryo transfer medicine.anatomical_structure Endocrinology Reproductive Medicine biology.protein hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biology of Reproduction. 84:560-571 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod.110.088187 |
| Popis: | Anti-Mullerian hormone (AMH) is an endocrine marker that can help predict superovulatory responses to treatments administered to cows for embryo production. However, the optimal time of the estrous cycle at which a blood test should be performed for a highly reliable prognosis has not yet been established. Moreover, little is known about the regulation of AMH production. To answer these questions, a study was designed to investigate the regulation of AMH production in cows selected for their high or low ovulatory responses to superovulation. At the granulosa cell level, AMH production was inhibited by follicle-stimulating hormone but enhanced by bone morphogenetic proteins. At the follicular level, the expression of AMH within the follicle was dependent on the stage of follicular development. At the ovarian level, the size of the pool of small antral growing follicles determined ovarian AMH production. At the endocrine level, AMH followed a specific dynamic profile during the estrous cycle, which occurred independently of the follicular waves of terminal follicular development. Cows selected for their high or low responses to superovulation did not differ in the regulation of AMH production, but cows with higher responses had higher plasma AMH concentrations throughout the cycle. The optimal period of the estrous cycle at which to measure AMH concentrations with the aim of selecting the best cows for embryo production was found to be at estrus and after Day 12 of the cycle. Based on this multiscale study, we propose a model that integrates the different regulatory levels of AMH production. |
| Databáze: | OpenAIRE |
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