Alternative pathways of angiotensin II production in the human saphenous vein

Autor:	Julie A.A. Borland, Karen Morrison, Magdi H. Yacoub, Adrian H. Chester
Rok vydání:	1998
Předmět:	Pharmacology medicine.medical_specialty Angiotensin II receptor type 1 biology Chymase Angiotensin-converting enzyme Captopril Angiotensin II Quinaprilat Endocrinology Losartan Internal medicine Renin–angiotensin system medicine biology.protein medicine.drug
Zdroj:	British Journal of Pharmacology. 125:423-428
ISSN:	0007-1188
DOI:	10.1038/sj.bjp.0702018
Popis:	1 The aim of our study was to demonstrate the existence, location and functional importance of an alternative angiotensin II-forming pathway other than angiotensin converting enzyme (ACE) in the human saphenous vein (SV). 2 Vascular reactivity studies using an in vitro organ bath technique showed that the SV (n=20) produced similar maximum contractions in response to angiotensin I (41.5±5.4 mN) compared to those observed to angiotensin II (46.7±10.9 mN). The response to angiotensin I could be significantly inhibited (P
Databáze:	OpenAIRE
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