Biodeactivation of Lipopolysaccharide Correlates with Surface‐Bound NO 3 After Cold Atmospheric Plasma Treatment
| Autor: | David B. Graves, Gottlieb S. Oehrlein, Pingshan Luan, Andrew J. Knoll, Joonil Seog, Elliot A. J. Bartis |
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| Rok vydání: | 2015 |
| Předmět: |
inorganic chemicals
010302 applied physics chemistry.chemical_classification Polymers and Plastics Lipopolysaccharide Biomolecule Analytical chemistry Atmospheric-pressure plasma 02 engineering and technology Polymer Sterilization (microbiology) 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences chemistry.chemical_compound chemistry 0103 physical sciences Surface chemical Surface modification 0210 nano-technology After treatment |
| Zdroj: | Plasma Processes and Polymers. 13:410-418 |
| ISSN: | 1612-8869 1612-8850 |
| Popis: | Cold atmospheric plasma (CAP) treatment of biological surfaces results in important changes of biological functions, but little knowledge on specific surface-chemical changes is available. We measured surface-bound NO3 on polymer and biomolecular films after CAP treatment. An O2/N2-based surface microdischarge was used to deactivate lipopolysaccharide (LPS), an immune-stimulating biomolecule found in Gram negative bacteria. The observed LPS biodeactivation was highest for low N2 concentrations in O2, increased roughly linearly with surface NO3, and then saturated. NO3 was also observed after treatment by a very different source: an atmospheric pressure plasma jet operating with an Ar carrier gas. Thus, NO3 formation is a generic surface chemical modification of these materials by CAP sources. |
| Databáze: | OpenAIRE |
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