An efficient synthesis of novel pyridothieno-fused thiazolo[3,2- a ]pyrimidinones via Pictet–Spengler reaction

Autor:	Jian-Nan Yang, Dong Wang, Dao-Lin Wang, Liang Yan, Guang-Yu Pan
Rok vydání:	2016
Předmět:	Pictet–Spengler reaction Pyrimidinones 010405 organic chemistry Chemistry Stereochemistry Condensation General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Isomerization 0104 chemical sciences Catalysis
Zdroj:	Chinese Chemical Letters. 27:953-956
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2016.02.007
Popis:	An efficient method for the synthesis of novel pyrido[3″,2″:4′,5′]thieno[3′,2′:2,3]pyrido [4,5:d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives (5) has been developed using a Pictet–Spengler reaction between 2-(3-aminothieno[2,3-b]pyridin-2-yl)thiazolo[3,2-a] pyrimidin-5-one (3), which could be obtained from the condensation of 7-(chloromethyl)-5H-thiazolo[3,2-a]pyrimidin-5-one (1) with 3-cyanopyridine-2-thione (2) via Thorpe–Ziegler isomerization, and aromatic aldehydes under NH2SO3H as catalysis in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82fe47007f51e4aa3cf2f6a4cbaec568 https://doi.org/10.1016/j.cclet.2016.02.007 Zobrazit plný text záznamu Full Text from ScienceDirect