New Disulfide-Linked Dinitroxides and the Kinetics of Their Reaction with Glutathione
| Autor: | Joseph P. Y. Kao, Nathaniel D. A. Dirda, Mitasha S. Palha, Gerald M. Rosen, Eric A. Legenzov |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Chemistry medicine.medical_treatment Kinetics Regulator Oxidative phosphorylation Glutathione 010402 general chemistry 01 natural sciences Redox Atomic and Molecular Physics and Optics 030218 nuclear medicine & medical imaging 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biochemistry medicine Thiol Xenobiotic |
| Zdroj: | Applied Magnetic Resonance. 52:945-955 |
| ISSN: | 1613-7507 0937-9347 |
| Popis: | The health of living systems depends on the proper balance of cellular oxidative and reductive processes (redox balance), which is reflected in the thiol-disulfide balance in cells. Glutathione is the predominant low-molecular-weight thiol in mammalian cells. Through its diverse actions as an antioxidant, as a detoxifier of xenobiotics, and as a regulator of protein function, among others, glutathione is vitally important to cell health. Spectroscopic probes that can act as sensors or reporters of glutathione are, therefore, useful. We report here the synthesis of three new disulfide-linked dinitroxides, whose EPR spectra change dramatically upon reaction with glutathione, and the characterization of the kinetics of their reaction with glutathione. |
| Databáze: | OpenAIRE |
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