Vitamin D supply and its relationship with nutritional status and survival in patients with liver cirrhosis
| Autor: | L. O. Pentiuk, S. V. Shevchuk, L. V. Moroz, T. V. Tkachenko |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Reports of Vinnytsia National Medical University. 27:79-85 |
| ISSN: | 2522-9354 1817-7883 |
| Popis: | Annotation. Prognosis assessment is critical for liver cirrhosis (LC). Vitamin D deficiency is considered a possible unfavorable factor. The aim of the study was to assess the level of vitamin D in LC patients, to establish the prevalence of its deficiency, and to determine the relationship with the severity of LC, nutritional status, and patient survival. 95 LC patients, 61 men, and 34 women (age 50.1±1.15 years) were enrolled in the prospective study. The nutritional status was assessed using Onodera’s Prognostic Nutritional Index (Onodera’s PNI). The serum 25(OH)D3 was determined by enzyme immunoassay. Statistical analysis was performed in SPSS v 21.0. It was established that vitamin D insufficient supply was present in 9% of LC patients, deficiency – in 74%, and severe deficiency – in 15% of patients. LC decompensation was accompanied by a worsening of vitamin D deficiency. The serum 25(OH)D3 was correlated with Child-Turcotte-Pugh and Model For End-Stage Liver Disease (r= -0.481, -0.487, respectively, p˂0.001). The lowest 25(OH)D3 levels were in patients with severe and refractory ascites, hepatic encephalopathy, and significant hypoalbuminemia. Malnutrition was found in 34.7% of decompensated patients and was associated with severe vitamin D deficiency. The 25(OH)D3 was correlated with Onodera’s PNI (r=0.679, p˂0.001). The 25(OH)D3 had a good predictive value for the 1-year mortality (AUC 0.708, p=0.004). The 25(OH)D3 less than 12.5 ng/ml should be considered a marker of a poor prognosis. Thus, vitamin D deficiency is highly prevalent in LC patients. It is associated with the severity of liver disease, malnutrition, and poor prognosis. Further studies are needed to determine whether vitamin D supplementation can improve survival in LC patients. |
| Databáze: | OpenAIRE |
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