19F-Grafted Fluorescent Carbonized Polymer Dots for Dual-Mode Imaging

Autor:	Leyu Wang, Suying Xu, Qiangqiang Nie, Chang Guo
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Fluorescence-lifetime imaging microscopy medicine.diagnostic_test Carbonization Dual mode Nanoprobe Nanotechnology Magnetic resonance imaging Polymer Fluorescence Analytical Chemistry chemistry medicine Biological imaging
Zdroj:	Analytical Chemistry. 93:13880-13885
ISSN:	1520-6882 0003-2700
DOI:	10.1021/acs.analchem.1c02661
Popis:	Dual-modal imaging systems could provide complementary information by taking advantage of each imaging modality. Herein, a fluorescence and 19F magnetic resonance imaging nanoprobe was developed through preparation of 19F-grafted fluorescent carbonized polymer dots (FCPDs). Both fluorescence and 19F nuclear magnetic resonance intensities of these FCPDs can be modulated by controlling the carbonization processes. The strong yellow fluorescence renders these FCPDs capable of cell fluorescence imaging. The in vitro and in vivo assessments demonstrated that the as-prepared FCPDs were suitable for 19F magnetic resonance imaging (19F MRI), which would provide great potential for biological imaging and early diagnosis applications. Moreover, this fabrication strategy offers a new protocol for 19F MRI nanoprobe design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82f40efe9cd22ef99924ba380af2eae5 https://doi.org/10.1021/acs.analchem.1c02661 Zobrazit plný text záznamu