ChemInform Abstract: One-Pot Synthesis of 3,4,5-Trisubstituted 1,2,4-Triazoles via the Addition of Hydrazides to Activated Secondary Amides

Autor:	André B. Charette, Inna S. Khazhieva, Elsa Rodriguez, William S. Bechara
Rok vydání:	2015
Předmět:	Chemistry Intramolecular force One-pot synthesis Triazole derivatives Moiety Surface modification General Medicine Combinatorial chemistry
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201529189
Popis:	A general approach has been developed for the one-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles from secondary amides and hydrazides via triflic anhydride activation followed by microwave-induced cyclodehydration. In addition, the 1,2,4-triazole moiety is shown to be a useful directing group for Ru-catalyzed C–H arylation. Access to 1,2,4-triazolophenanthridine can be achieved from the reaction products using a Pd-catalyzed intramolecular C–H functionalization reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82f331f202a7dd6de99512b3c614ac79 https://doi.org/10.1002/chin.201529189 Zobrazit plný text záznamu Plný text