Synthesis and Antimicrobial Properties of Chiral Mannich Bases Containing a Norbornene Fragment

Autor:	E. H. Mammadbayli, S. V. Ismayilova, L. M. Maharramova, G. E. Hajieva
Rok vydání:	2021
Předmět:	biology Klebsiella pneumoniae Organic Chemistry Formaldehyde Carbon-13 NMR medicine.disease_cause Antimicrobial biology.organism_classification Dextrorotatory chemistry.chemical_compound chemistry Staphylococcus aureus medicine Organic chemistry Escherichia coli Norbornene
Zdroj:	Russian Journal of Organic Chemistry. 57:936-941
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428021060087
Popis:	New Mannich bases were synthesized from chiral norbornenylmethanol, secondary amines, and formaldehyde. Their structure was confirmed by elemental analyses and IR, 1H and 13C NMR, and mass spectra. The products were optically active (dextrorotatory), and they showed high antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and yeast-like fungi of the family Candida, which exceeded the activity of some drugs currently used in medical paractice. Minimum inhibitory and minimum bactericidal concentrations of the synthesized compounds were determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82da1523f8687ac8c3917bd69c7e0ef9 https://doi.org/10.1134/s1070428021060087 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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