| Autor: |
Sabrina Katzdobler, Alexander Nitschmann, Henryk Barthel, Gerard Bischof, Leonie Beyer, Ken Marek, Mengmeng Song, Olivia Wagemann, Carla Palleis, Endy Weidinger, Anne Nack, Urban Fietzek, Carolin Kurz, Jan Häckert, Theresa Stapf, Christian Ferschmann, Maximilian Scheifele, Florian Eckenweber, Gloria Biechele, Nicolai Franzmeier, Anna Dewenter, Sonja Schönecker, Dorothee Saur, Matthias L. Schroeter, Jost-Julian Rumpf, Michael Rullmann, Andreas Schildan, Marianne Patt, Andrew W. Stephens, Thilo Eimeren van, Bernd Neumaier, Alexander Drzezga, Adrian Danek, Joseph Classen, Katharina Bürger, Daniel Janowitz, Boris-Stephan Rauchmann, Sophia Stöcklein, Robert Perneczky, Florian Schöberl, Andreas Zwergal, Günter U. Höglinger, Peter Bartenstein, Victor Villemagne, John Seibyl, Osama Sabri, Johannes Levin, Matthias Brendel |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1269572/v1 |
| Popis: |
Purpose Early after [18F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [18F]PI-2620 tau-PET is able to discriminate 4-repeat tauopathies (4RTs) from disease controls and healthy controls. Here, we investigated whether early-phase [18F]PI-2620 PET has an additive value for biomarker based evaluation of 4RTs. Methods Seventy-eight patients with 4RTs (71±7y, 39 female), 79 patients with other neurodegenerative diseases (67±12y, 35 female) and twelve age-matched controls (69±8y, 8 female) underwent dynamic (0-60 min) [18F]PI-2620 PET imaging. Regional perfusion (0.5-2.5 min p.i.) and tau load (20-40 min p.i.) were measured in 246 predefined brain regions [standardized-uptake-value-ratios (SUVr), cerebellar reference]. Regional SUVr were compared between 4RTs and controls by an ANOVA including false-discovery-rate (FDR, p18F]PI-2620 perfusion imaging mirrors known topology of regional hypoperfusion in 4RTs. Single region hypoperfusion is not specific for 4RTs, but perfusion pattern expression provides an additive value for the discrimination of 4RTs from other neurodegenerative diseases and correlates closer with clinical severity than tau pattern expression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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