Effects of Acute and Chronic Treatment with the Sodium Hydrogen Exchanger 1 (NHE-1) Inhibitor Cariporide on Myocardial Infarct Mass in Rabbits with Hypercholesterolaemia
| Autor: | Udo Dr Albus, Oliver Jung, Wolfgang Linz, Hans-Jochen Lang, Andreas E. Busch |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
medicine.medical_specialty Normal diet Cariporide business.industry Cholesterol Infarction General Medicine Toxicology medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Circulatory system medicine Myocardial infarction Endothelial dysfunction business Lipoprotein |
| Zdroj: | Basic & Clinical Pharmacology & Toxicology. 95:24-30 |
| ISSN: | 1742-7835 |
| DOI: | 10.1111/j.1742-7843.2004.t01-1-pto950105.x |
| Popis: | We investigated the cardioprotective effect of acute and chronic sodium hydrogen exchanger 1 (NHE-1) inhibition with cariporide under pathological conditions in rabbits fed an atherogenic diet (0.25% cholesterol, 3% coconut oil), an experimental model of atherosclerosis. New Zealand White rabbits were fed over 4 weeks with normal diet or with atherogenic diet and randomized in 3 subgroups (n=7 in each group); placebo, acute cariporide (0.3 mg/kg, 10 min. before occlusion of left anterior descending coronary artery and chronic cariporide (4 weeks 0.1% in chow). In the final infarction experiments the animals were subjected to 30 min. of myocardial ischaemia by occlusion of a branch of the left anterior descending coronary artery followed by 2 hr of reperfusion. Infarct mass was evaluated by triphenyl-tetrazolium chloride staining and the infarct size expressed as a percentage of area at risk. Besides the assessment of aortic endothelium-dependent function aortic and cardiac vessels were inspected for atherosclerotic lesions. In cholesterol-fed rabbits, the infarct size was significantly increased when compared with normal diet animals (63+/-3% versus 41+/-3%). Acute cariporide treatment reduced the infarct size in normal diet rabbits to 14%+/-3% (66% decrease, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|