Structures of topostins, DNA topoisomerase I inhibitors of bacterial origin

Autor:	Youji Sakagami, Takayuki Nemoto, Makoto Ojika, Yoshinori Takahata, Toshiwo Andoh
Rok vydání:	1998
Předmět:	DNA Topoisomerase I Inhibitors chemistry.chemical_classification biology Biochemistry chemistry Flexibacter Organic Chemistry Drug Discovery biology.organism_classification Bacteria Amino acid
Zdroj:	Tetrahedron. 54:2683-2690
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(98)83004-4
Popis:	The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibacter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of original topostins B (B553 (1) and B567 (2)) and new related compounds named topostins D (D640 (3) and D654 (4)). Their structures, including the absolute stereochemistry, were determined by spectroscopic analyses and chemical degradations. These substances are lipid-containing amino acids and peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::82d6c14f4a243c713c436bb2633962d8 https://doi.org/10.1016/s0040-4020(98)83004-4 Zobrazit plný text záznamu Full Text from ScienceDirect