Frequency of use and outcome of surgical resection in the management of malignant mesothelioma in a community-based population: Results in 5,937 patients
| Autor: | Prasad S. Adusumilli, Valerie W. Rusch, Raja M. Flores, Jessica S. Donington, Michele Carbone, K. E. Rosenzweig, Lee M. Krug, Harvey I. Pass, Elyn Riedel |
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| Rok vydání: | 2009 |
| Předmět: |
Surgical resection
Community based Cancer Research medicine.medical_specialty education.field_of_study business.industry Proportional hazards model General surgery Population Multimodality Therapy medicine.disease Surgery Oncology Epidemiology Medicine Mesothelioma Stage (cooking) business education |
| Zdroj: | Journal of Clinical Oncology. 27:7510-7510 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2009.27.15_suppl.7510 |
| Popis: | 7510 Background: Multimodality therapy of mesothelioma patients treated at specialized tertiary hospitals report surgical resection rates of 42% (Flores RM et al. Prognostic Factors in the Treatment of Malignant Pleural Mesothelioma at a Large Tertiary Referral Center. J Thorac Oncol 2007;2(10):957–965.). Treatment strategies in the community are less well defined and surgical expertise is not readily available. We undertook this study to evaluate the rate of surgical resection and its association with survival in a non-tertiary based population. Methods: The Surveillance, Epidemiology, and End Results (SEER) database was searched from 1990 - 2004. Variables analyzed included age, sex, race, year of diagnosis, laterality, vital status, stage, surgery, and reasons for no surgery. The association of resection on overall survival was estimated by the Kaplan-Meier method and examined in a Cox proportional hazards model adjusting for covariates. Results: Pathologically proven malignant pleural mesothelioma was identified in 5,937 patients: 1,166 women, 4,771 men; median age was 70 years. Surgical resection rate was 11% (n=636). Univariate analysis demonstrated a median survival of 13 months with surgical resection and a median survival of 7 months in the non-resected group (p No significant financial relationships to disclose. |
| Databáze: | OpenAIRE |
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