Bismuth accumulates in the body during treatment with tripotassium dicitrato bismuthate
| Autor: | J. Sercombe, Roy E. Pounder, M.‐L. Szeto, C. J. Gavey, Chuka U. Nwokolo |
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| Rok vydání: | 2007 |
| Předmět: |
inorganic chemicals
Hepatology Urinary system Inorganic chemistry Bismuthate Radiochemistry Gastroenterology chemistry.chemical_element Urine bacterial infections and mycoses equipment and supplies digestive system digestive system diseases Bismuth Excretion chemistry.chemical_compound chemistry Pharmacology (medical) After treatment |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 3:21-28 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1989.tb00187.x |
| Popis: | Bismuth concentration was measured in plasma, dried leucocytes and urine in nine patients before, during and after treatment with tripotassium dicitrato bismuthate (De-Noltab 2 b.d.) for 6 weeks. During treatment there was an 8.5-fold rise in median plasma bismuth concentration (P less than 0.01), a non-significant doubling of leucocyte bismuth content, and a 349-fold rise in 24-h urinary bismuth excretion (P less than 0.01). The significantly increased urinary bismuth excretion continued for at least 3 months after cessation of treatment with tripotassium dicitrato bismuthate, indicating accumulation of bismuth during treatment with this drug. |
| Databáze: | OpenAIRE |
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